Formulation and Pharmacokinetics of Vitamin E TPGS Melt Dispersion Granules: An Approach to Improve Oral Delivery of Flurbiprofen

Oral drug delivery is considered as the most preferable route for chronic treatment of various diseases, due to its greater stability, flexibility in formulation, dosage accuracy, low cost of manufacturing and packaging and patient friendly administration [1]. But most of the drugs belong to poorly water soluble (BCS Class II) category and suffering from poor dissolution and it is worst if given in the form of solid dosage forms like tablets [2]. Hence BCS Class II drugs required to improve the solubility/dissolution to give as oral solid dosage forms. One of the widely used approaches to enhance the solubility and dissolution rate of poorly water soluble drugs is a well-known process of fabricating solid dispersions [3].